Download e-book for iPad: Computational Methods in Systems Biology: International by Sergio Pozzi, Gianluca Della Vedova, Giancarlo Mauri

By Sergio Pozzi, Gianluca Della Vedova, Giancarlo Mauri (auth.), Vincent Danos, Vincent Schachter (eds.)

ISBN-10: 3540253750

ISBN-13: 9783540253754

The Computational tools in structures Biology (CMSB) workshop sequence was once tested in 2003 by way of Corrado Priami. the aim of the workshop sequence is to aid catalyze the convergence among desktop scientists attracted to language layout, concurrency idea, software program engineering or application verification, and physicists, mathematicians and biologists attracted to the systems-level realizing of mobile tactics. structures biology was once perceived as being more and more looking for subtle modeling frameworks even if for representing and processing syst- point dynamics or for version research, comparability and refinement. One has the following a uncomplicated case of a must-explore box of program for the formal tools built in machine technology within the final decade. This complaints involves papers from the CMSB 2003 workshop. a superb 3rd of the 24 papers released the following have a unique formal tools beginning; we take this as a affirmation synergy is development that may aid solidify CMSB as a discussion board for cross-community trade, thereby starting new theoretical avenues and making the sector much less of a possible software and extra of a true one. book in Springer's new Lecture Notes in Bioinformatics (LNBI) bargains specific visibility and influence, which we gratefully recognize. Our keynote audio system, Alfonso Valencia and Trey Ideker, gave difficult and just a little humbling lectures: they made it transparent that powerful purposes to platforms biology are nonetheless a way forward. We thank all of them the extra for accepting the invitation to talk and for the readability and pleasure they delivered to the conference.

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Extra resources for Computational Methods in Systems Biology: International Conference CMSB 2004, Paris, France, May 26-28, 2004, Revised Selected Papers

Example text

The function fjoin determines the actual interface of the bio-process resulting from the aggregation of boxes, as well as possible renamings of the enclosed pi-processes. A simple instance of fjoin is the following: λB 1 B 2 P1 P2 . if (B 1 = B ∗1 β(x : Γ ) and B 2 = B ∗2 β(y : ∆) and Γ ∩ ∆ = ∅) then (B 1 , σid , {x/y }) else ⊥ (4) where σid stays for the identity substitution and ⊥ for undefinedness. Assuming the above definition of the function fjoin , the axiom join corresponds to the graphical reduction drawn below.

Depending on the concentration of hnRNP A1, eff 3 is given by the formula eff 3 (hnRNPA1 ) = η·PESE t ·(ASF +SC35 )·(kESS 2a ·(kESS 2b +SC35 )+hnRNPA1 ·kESS 2b ) η ·(kESE +ASF +SC35 )·PESS 2 ·hnRNPA1 ·kESS 2b (1) A similar approach for the acceptor site A7 yields an efficiency function eff 7 , integrating the effects of SR and Rev proteins: eff 7 (hnRNPA1 , rev) = PESE 3 ·ASF kESE 3b ·(1+ hnRNPA1 )+ASF k PISS ·hnRNPA1 kISS +hnRNPA1 ESE 3 + + PESS 3ab ·SC35 kESS 3ab +SC35 PESS 3b ·hnRNPA1 kESS 3b +hnRNPA1 + PRRE ·rev kRRE +rev (2) Building and Analysing an Integrative Model of HIV-1 RNA 47 In both formulas, Px > 0 (resp.

Boxes delimitate the sequence of encoded proteins (ORF). In the mRNAs, spliced introns are designated by dotted lines, and exons by thick lines The competing sites A3 to A5 are used to produce major viral proteins. Experimental studies show that these sites are regulated. Site A3 can be inhibited by the binding of the protein hnRNP A1 to the ESS2 (Exon Splicing Silencer) element, or activated by fixation of SR proteins to the ESEt (Exon Splicing Enhancer) element. SC35 proteins can also bind to the ESS2 element.

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Computational Methods in Systems Biology: International Conference CMSB 2004, Paris, France, May 26-28, 2004, Revised Selected Papers by Sergio Pozzi, Gianluca Della Vedova, Giancarlo Mauri (auth.), Vincent Danos, Vincent Schachter (eds.)


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