By Marc E. Rothenberg
Provides greater than 2200 references to inspire ongoing study! This unique quantity synthesizes the newest breakthroughs within the fields of hypersensitive reaction and chemokines leading to cutting edge paradigms and new strategies about the foundation and therapy of allergic illnesses. Considers the organic homes of approximately 60 structurally comparable chemokines and over a dozen receptors! shaped to provide an updated evaluate of molecular constitution, gene law, organic homes, and sign transduction pathways, Chemokines in Allergic sickness ·documents the emergence of chemokines as an immense great kinfolk of chemoattractant cytokines that advertise the activation and improvement of leukocytes ·illuminates the approaches that regulate leukocyte accumulation ·links chemokines with mobile recruitment and activation in allergic sickness ·explores some great benefits of pharmaceutical intervention within the chemokine pathway ·covers the basic biochemistry, molecular biology, and actual constitution of chemokines and their receptors ·describes transcriptional law of chemokine expression ·discusses virally triggered gene expression as a major set off of allergic responses in young children ·analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages ·elucidates the mobile community focused on the iteration of chemokines in allergic illnesses ·highlights pharmaceutical methods for the advance of chemokine structural analogs, receptor antagonists, and inhibitors of sign transduction ·offers healing options for interfering with chemokines in allergic problems ·and extra! With contributions from forty six across the world revered clinicians, Chemokines in Allergic sickness is an integral reference for uncomplicated and scientific immunologists; allergists; pulmonologists and pulmonary ailment experts; physiologists; molecular, mobile, and lung biologists; pediatricians; internists; and graduate and scientific institution scholars in those disciplines.
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Additional info for Chemokines in Allergic Disease
Proudfoot, Christine A. Power, and Timothy Wells 509 24. Chemokine Receptor Blockade Paul D.
I. Proudfoot, Christine A. Power, and Timothy Wells 509 24. Chemokine Receptor Blockade Paul D.
M. Zack Howard, and Joseph A. Hedrick 17 3. Chemokine Receptors Philip M. Murphy and Marc E. Rothenberg 53 4. Three-Dimensional Structure of Chemokines Martin J. Stone and Kristen R. Mayer 67 II. Basic Science of Chemokines and Allergic Disease 5. Animal Allergy Models: Dissecting Chemokine Function D. M. Conroy and Timothy Williams 95 6. Transcriptional Regulation of Chemokines Ya-Fen Chen, An Song, and Alan M. Krensky 115 7. Chemokines and Histamine-Releasing Factors Allen P. [/PU][DP]2000[/DP]End of Citation Page viii 8.
Chemokines in Allergic Disease by Marc E. Rothenberg