By Olimpia Meucci (auth.), Olimpia Meucci (eds.)
Chemokines and their receptors are being famous as an fundamental portion of the fearful approach implicated in primary points of improvement and homeostasis, akin to neurotransmission, proliferation, differentiation, and neuronal-glial conversation. hence, their involvement in HIV neuropathology is going a long way past the co-receptors position and involves advanced interactions of the chemokine process with assorted mobilephone varieties and different regulators of neuronal functionality. the most important target of this quantity is to check those issues for you to spotlight changes of chemokine body structure which can give a contribution to neuroAIDS and different neuropathologies.
This ebook can be of curiosity to neuroscientists, neurologists, virologists, pharmacologists, and scholars in those fields.
About the Editor:
Olimpia Meucci, MD, PhD is a Professor of Pharmacology and body structure & Microbiology and Immunology at Drexel collage university of medication in Philadelphia, PA. on the grounds that her seminal discovery concerning the rules of neuronal signaling through chemokines, her examine has basically eager about the physio-pathological roles of this significant type of neuroimmune modulators within the relevant frightened approach and their involvement in neuroAIDS. those stories have considerably contributed to present knowing of the mobile and molecular mechanisms of HIV-related neuropathology together with the interplay of the chemokine process with drug of abuse, specifically opiates, which is still a tremendous quarter of research within the Meucci lab.
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Extra info for Chemokine Receptors and NeuroAIDS: Beyond Co-Receptor Function and Links to Other Neuropathologies
Likewise, CNS manifestations of HIV-infection have also been modified by HAART. The severity of neurocognitive impairment has been lessened but not to a point where it has no impact on the quality of life, as even minor impairment can negatively affect survival. As systemic eradication of the virus is likely not possible in the near future, we are faced with addressing when and what types of therapies to initiate. The current guidelines for administering HAART recommend deferring therapy for asymptomatic patients until CD4 T + cell counts drop below 350.
Neuropsychologia 42(6):801–809 Xin KQ, Hamajima K, Hattori S, Cao XR, Kawamoto S, Okuda K (1999) Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system. AIDS Res Hum Retroviruses 15(16):1461–1467 Yeh MW, Kaul M, Zheng J, Nottet HS, Thylin M, Gendelman HE, Lipton SA (2000) Cytokinestimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. J Immunol 164(8):4265–4270 Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra CM, Meyerhoff DJ, Jarvik JG, Kolson D, Schifitto G, Ellis RJ, Swindells S, Simpson DM, Miller EN, Gonzalez RG, Navia BA (2004) Regional patterns of brain metabolites in AIDS dementia complex.
Proc Natl Acad Sci U S A 95(24): 14500–14505 Meucci O, Fatatis A, Simen AA, Miller RJ (2000) Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A 97(14):8075–8080 Meucci O, Miller RJ (1996) gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: protective action of TGF-beta1. J Neurosci 16(13):4080–4088 Meyerhoff DJ, MacKay S, Bachman L, Poole N, Dillon WP, Weiner MW, Fein G (1993) Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging.
Chemokine Receptors and NeuroAIDS: Beyond Co-Receptor Function and Links to Other Neuropathologies by Olimpia Meucci (auth.), Olimpia Meucci (eds.)