Download e-book for kindle: Cancer Metastasis -- Related Genes (CANCER METASTASIS -- by D.R. Welch

By D.R. Welch

ISBN-10: 0306478218

ISBN-13: 9780306478215

ISBN-10: 1402005229

ISBN-13: 9781402005220

This quantity is the 1st try and summarize present wisdom in regards to the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. whereas all prior authors tried to place their findings right into a context for translation to the medical state of affairs, the state-of-the-art doesn't totally enable this as the box of metastasis is comparatively new. still, the contents of this quantity may be of use to participants of the melanoma examine neighborhood and clinicians drawn to constructing and enforcing novel different types of therapy for melanoma.

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Additional info for Cancer Metastasis -- Related Genes (CANCER METASTASIS -- BIOLOGY AND TREATMENT Volume 3) (Cancer Metastasis - Biology and Treatment)

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Nagabhushan M, Pretlow TG, Guo YJ, Amini SB, Pretlow TP, Sy MS. Altered expression of CD44 in human prostate cancer during progression. Am J Clin Pathol 1996; 106:647-51. 124. De Marzo AM, Bradshaw C, Sauvageot J, Epstein JI, Miller GJ. CD44 and CD44v6 downregulation in clinical prostatic carcinoma: relation to Gleason grade and cytoarchitecture. Prostate 1998; 34:162-8. 125. Noordzij MA, van Steenbrugge GJ, Verkaik NS, Schroder FH, van der Kwast TH. The prognostic value of CD44 isoforms in prostate cancer patients treated by radical prostatectomy.

30 108. Wei LL, Yang X, Phillips K, Weissman BE, Welch DR. Proc. Am. Assoc. Cancer Res. 1996; 37:76. 109. Takaoka A, Hinoda Y, Sato S, et al. Reduced invasive and metastatic potentials of KAI1-transfected melanoma cells. Jpn J Cancer Res 1998; 89:397-404. 110. Takaoka A, Hinoda Y, Satoh S, et al. Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene. Oncogene 1998; 16:1443-53. 111. Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC. Loss of KAI1 expression in the progression of colorectal cancer [In Process Citation].

The mechanism of action for the metastasis-suppressor protein from the gene on chromosome 6 was studied using a variety of in vitro and in vivo techniques. The neo6/C8161 cells were still locally invasive and cells were even detected in efferent vessels. This finding implied that the step(s) in the metastatic cascade inhibited by introduction of chromosome 6 occurred subsequent to intravasation. The identity of those steps was not further elucidated using in vitro assays mimicking adhesion, invasion, motility, or growth.

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Cancer Metastasis -- Related Genes (CANCER METASTASIS -- BIOLOGY AND TREATMENT Volume 3) (Cancer Metastasis - Biology and Treatment) by D.R. Welch


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