Download e-book for iPad: Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in by Steven H. Abman

By Steven H. Abman

ISBN-10: 1420076914

ISBN-13: 9781420076912

Rising treatments for BPD - corresponding to Inhaled Nitrous Oxide, diet A, Antioxidant options, and low-dose steroid remedy

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Extra resources for Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in Health and Disease)

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J Clin Invest 2000; 106:1311–1319. 27. Massaro GD, Massaro D. Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 1996; 270:L305–L310. 28. Massaro GD, Massaro D. Retinoic acid treatment partially rescues failed septation in rats and in mice. Am J Physiol Lung Cell Mol Physiol 2000; 278:L955–L960. 29. McGowan S, Jackson SK, Jenkins-Moore M, et al. Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers.

Wu JY, Feng L, Park HT, et al. The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 2001; 410:948–952. 19. Anselmo MA, Dalvin S, Prodhan P, et al. Slit and Robo: expression patterns in lung development. Gene Expr Patterns 2003; 3:13–19. 20. Xian J, Clark KJ, Fordham R, et al. Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Proc Natl Acad Sci U S A 2001; 98:15062–15066. 21. Chen C, Chen H, Sun J, et al.

7-kb human SP-C promoter, causes abnormal lung morphogenesis with cystic terminal sacs (122). In contrast, SP-C promoter-driven overexpression of either the BMP antagonist Xnoggin or the Gremlin to block BMP signaling results in severely reduced distal epithelial cell phenotypes and increased proximal cell phenotypes in the lungs of transgenic mice (51). Interestingly, blockade of endogenous BMP4 in embryonic mouse lung epithelial cells using a conditional gene knockout approach results in abnormal lung development with similar dilated terminal sacs as seen in BMP4 transgenic mouse lung (123), suggesting that appropriate level of BMP4 is essential for normal lung development.

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Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in Health and Disease) by Steven H. Abman


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