By Claudio Nicolini (auth.), Claudio Nicolini (eds.)
This accomplished advisor to the biophysics of metalloproteins and the mechanisms of cost move via structures concerning them, goals to stipulate a precis of clinical effects got by way of the world-wide study lately. the amount seems to be at a time of important development in the box, whilst applied sciences derived from it are granted critical acceptance for his or her function within the improvement of biotechnology, electronics and fabric sciences.
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Extra resources for Biophysics of Electron Transfer and Molecular Bioelectronics
1990, Langmuir-Blodgett films ofimmunoglobulines as sensing elements, // Nuovo Cimento 120:1253-1258. , 1994, Reversed micellar approach as a new tool for the formation and structural studies ofprotein Langmuir-Blodgett films, Thin Solid Films 238:88. , 1993, Nanogravimetriegauge for surface density measurements and deposition analysis ofLangmuir-Blodgett films, Thin Solid Films 230:86-89. , 1994, Scanning tunnelling microscopy ofa monolayer ofreaction centres, Thin Solid Films 243:403-406. , 1997, Formation and characterization ofan ultrathin semiconductor polycrystallayer for transducer applications, Biosensors & Bioe/eetronies 12:607-611.
This ability is critical to assess the roJe of individual isozymes in drug metabolism, carcinogen activation or deactivation and also in the development of novel biocatalysts etc. (Waterman, 1994) However, the direct application of the heterologously expressed P450 proteins for the above mentioned purposes is limited at present by several factors: 1) The in vivo heterologous cytochrome P450 expression systems may not exactly reflect the pattems of xenobiotic and drug metabolism in human body due to the differences between the microorganisms and animal cells in the mechanisms, responsible for the transport and processing of cytochrome P450 substrates and products; 26 2) The expression Ievels may vary significantly depending on a particular P450 isoform: 3) The reactivity and stability ofthe heterologusly expressed cytochromes may not be sufficient enough to enable the long-term preservation of their properties; 4) the utilization of reconstituted systems requires the use of redox partner proteins and expensive reductants.
1991, A photocell based on a high concentration of Chromatophore, Biochemistry and Bioenergetics 26:117-122. , 1994, Tunneling mechanism in electron-transfer - a view from the feynmans path-integral approach, Chem. Phys. , 227:170-179. , 1994. Study ofthe conformational stability of cytochrome C at the air-water interface, Thin Solid Films 247:240-243. , 1987, Cellular automata machines, MIT Press, Cambridge (Mass. USA). , 1990, Physica D 45:229. , 1995, Comparative study ofLangmuir mono1ayers ofimmunog1obu1ines g formed at the air-water interface and covalent1y immobilized on solid supports, Langmuir 11:385-389.
Biophysics of Electron Transfer and Molecular Bioelectronics by Claudio Nicolini (auth.), Claudio Nicolini (eds.)