By W.-H. Boehncke (Editor), H.H. Radeke (Editor)
This is often the 1st publication to hide each attitude within the medical program of biologics. Readers won't basically locate that every one of the biologics at present authorized for scientific use are delineated in a standardized method, but additionally the "differential treatment" with biologics in fields together with dermatology and neurology is defined intimately and summarized in remedy algorithms. Shorter sections on biologic biotechnology in addition to safeguard and regulatory concerns supplement the extra clinically-oriented critical chapters.
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Additional info for Biologics in General Medicine
2005) Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-. Gastroenterology 128:376 – 392 Murch SH, Lamkin VA, Savage MO, Walker-Smith JA, MacDonald TT (1991) Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease. Gut 32:913 – 917 Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT (1993) Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.
However, several in vitro studies, particularly with infliximab and etanercept, have yielded conflicting results regarding the induction of apoptosis in T cells and monocytes by TNF antagonists (Catrina et al. 2005; Mitoma et al. 2005; Shen et al. 2005; van den Brande et al. 2003), and the relevance of these in vitro studies to the efficacy or safety of these agents in vivo remains to be determined. 2 Indications Adalimumab is indicated for the treatment of moderate to severe active RA in adult patients when the response to disease-modifying antirheumatic drugs (DMARDs) including MTX has been inadequate, and for the treatment of severe, active, and progressive RA in adults not previously treated with MTX.
2005) Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept. Aliment Pharmacol Ther 21(3):251 – 258 van den Brande JM, Braat H, van den Brink GR, et al. (2003) Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease. , for the Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group (2005) Efficacy and safety of infliximab in patients with ankylosing spondylitis: results of a randomized, placebo-controlled trial (ASSERT).
Biologics in General Medicine by W.-H. Boehncke (Editor), H.H. Radeke (Editor)