By Michael R. Trimble, Mark S. George
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Extra resources for Biological Psychiatry, Third Edition
The coding region consists of sequences that will either appear in the mature mRNA (exons) or be deleted (introns). During meiosis, the strands from the two chromosomes become reattached to each other, but each chromosome carries a different allele. There is then a new combination of alleles in the next generation, this exchange being referred to as recombination. 4). Linkage analysis places the location of a particular gene on a chromosome; physical mapping deﬁnes the linear order among a series of loci.
The initial breakthroughs (see chapters on individual diseases) have not been replicated in many cases. This relates partly to difﬁculties of clinical diagnosis and partly to problems of genetic modelling. Thus, the same data set is used to generate the lod score that is used to construct the model for inheritance in the ﬁrst place. Building on the world of genomics (study of genes), scientists are now investigating the world of proteomics (the study of the proteins an individual expresses, which change over time).
Sodium and chloride are at lower concentrations on the inside of the cell; the other two have higher concentrations. At rest, the potential is maintained by the action of the sodium pump, which, at the expense of energy, forces the sodium out and draws the potassium in. The resting potential acts as the energy store of the cell, and neuronal action is dependent on it. The electrical signals of the nerve cells result from a change in the resting potential with alteration of the distribution of ions on either side of the membrane.
Biological Psychiatry, Third Edition by Michael R. Trimble, Mark S. George