Download PDF by Atta-ur-Rahman: Bioactive Natural Products Vol 34 Part N

By Atta-ur-Rahman

ISBN-10: 0444531807

ISBN-13: 9780444531803

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4 IlM, respectively). In order to further explore the antitumor potential of tylophorinerelated compounds in light of the NCI screening results, Gao et al. [10] synthesized four tylophorine analogs, designated NSC-717335 [S-(+)tylophorine, (+)-1], 105, 106, and 107 (NSC-716802), Fig. (11). All of the tylophorine analogs exerted potent growth-inhibitory effects against HepG2, a human hepatocellular carcinoma cell line, and KB, a human nasopharyngeal carcinoma cell line. These novel tylophorine derivatives 27 had similar activIty against parent KB cells and several KB sub-lines resistant to a current antitumor agent, including etoposide, hydroxyurea, and camptothecin.

Tetrahedron Letters 1988,29,4125-4128. Nordlander, J. ; Njoroge, F. G. J Org. Chern. 1987,52,1627-1630. Comins, D. ; Morgan, 1. A. Tetrahedron Letters 1991. 32, 5919-5922. Comins, D. ; Morgan, 1. A. J Org. Chern. 1997,62,7435-7438. Pearson, W. -C. Tetrahedron Letters 1990,31,7571-7574. Pearson, W. ; Schkeryantz, J. M. J Org. Chern. 1992, 57,6783-6789. Pearson, H. ; Walavalkar, R. Tetrahedron 1994, 50, 12293-12304. Ciufolini, A. ; Roschangar, F. J Am. Chern. Soc. 1996, 118, 12082-12089. ; Grandc1audon, P.

The mechanisms of action of these compounds were perceived to be similar if not identical, with only their potencies being different (tylophorine, tylocrebrine and cryptopleurine were less potent than emetine). In 2004, NSC-717335 [S(+)-tylophorine)] and NSC-716802 (105), similarly to taxol and nocodazole (non-DNA targeting compounds), failed to induce p53 and p21 expression in the study of Gao et al. The tumor suppressor protein p53 is known as a critical sensor of DNA damage, and induction of p53 is a key cellular event in response to DNA-damaging agents [81-83].

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Bioactive Natural Products Vol 34 Part N by Atta-ur-Rahman

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