By Richard F. Lockey, F. Lockey Richard, Samuel C. Bukantz, Jean Bousquet
Enlarged to explain greater than a decade of advances within the immunotherapy of allergic ailments and bronchial asthma, this 3rd variation includes the newest reviews at the mechanisms, manufacture, and standardization of assorted allergen teams and their usage within the therapy of allergic diseasesвЂ”containing eight new chapters detailing a variety of pharmacoeconomic, regulatory, production, management, and questions of safety touching on new and rising immunotherapy strategies.
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Extra resources for Allergens and Allergen Immunotherapy
Meltzer SJ. Bronchial asthma as a phenomenon of anaphylaxis. J Am Med Assoc 1910; 55:1021. 26. Otto R. Zur frage der serum-ueberempfindlichkeit. Munch Med Wschr 1907; 54:1664. 27. Besredka A, Steinhardt E. De l’anaphylaxie et de l’antianaphylaxie vis-a-vis due serum de cheval. Ann Inst Pasteur 1907; 21:117, 384. 28. Colebrook L. Almoth Wright. Provocative Doctor and Thinker. , 1954:61. 29. Noon L. Prophylactic inoculation against hay fever. Lancet 1911; 1:1572. 30. Freeman J. Vaccination against hay fever; report of results during the last three years.
An immune-mediated blocking of histamine was postulated through injections of a histamine-linked antigen [(histamine-azo-depreciated horse serum) “hapamine”] to induce antihistamine antibodies (190). While some of these modalities were initially encouraging, later studies failed to confirm their benefit. Favorable symptomatic improvements of empirical but nonspecific, treatment designed to modulate immune functions could not be determined without controlled clinical trials. The use of these agents fell by the wayside as new scientific knowledge of mechanisms of allergy were acquired (191).
Mary’s Hospital in London. ” Wright’s enthusiasm was reflected in his frequent prediction that “the physician of the future may yet become an immunisator” (28). Noon (Fig. ” To accomplish active immunization, he initiated clinical trials in 1910 with a series of subcutaneous injections of dosages of pollen extracts calculated on a pollen-derived weight basis (Noon unit), and thus introduced preseasonal immunotherapy. Noon’s observations provided the following (still pertinent) guidelines: Allergen Immunotherapy in Historical Perspective 11 Figure 8 Leonard Noon (1877–1913).
Allergens and Allergen Immunotherapy by Richard F. Lockey, F. Lockey Richard, Samuel C. Bukantz, Jean Bousquet