By Martin J. Pfeiffer, Martin Stehling, Anna Jauch (auth.), Hossein Baharvand, Nasser Aghdami (eds.)
Advances in Stem phone Research discusses contemporary advances in stem telephone technology, together with healing purposes. This quantity covers such themes as biomanufacturing iPS cells for healing purposes, strategies for controlling stem phone destiny judgements, in addition to present uncomplicated learn in such components as germ line stem cells, genomics and proteomics in stem mobile study. it's a necessary booklet for biology and scientific scientists, in particular younger investigators and stem mobile biology scholars who're newly coming into the realm of stem cells study. The editors desire that the hot wisdom and examine defined during this e-book may help give a contribution to new remedies for a wide selection of illnesses that almost immediately afflict humanity.
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Extra resources for Advances in Stem Cell Research
Thus these particular mutations seem to provide stem cells with an intrinsic growth advantage, and may be very difficult to completely avoid. On the other hand, altered culture conditions might also affect the mutation rate. 5 Can Culture Adapted Cells be Utilised in Regenerative Medicine? It is unlikely that mutation in ES cells will ever be completely prevented, and so eventual culture adaptation after a period in culture is perhaps unavoidable. Given this, it is pertinent to ask how hazardous these cells may be, and whether, in fact, culture adaptation actually presents any opportunities for research and regenerative medicine.
Stem Cell Res 4(1):50–56 2. Holliday R (1989) Chromosome error propagation and cancer. Trends Genet 5(2):42–45 3. Draper JS, Moore HD, Ruban LN, Gokhale PJ, Andrews PW (2004) Culture and characterization of human embryonic stem cells. Stem Cells Dev 13(4):325–336 4. Baker DE, Harrison NJ, Maltby E, Smith K, Moore HD, Shaw PJ, Heath PR, Holden H, Andrews PW (2007) Adaptation to culture of human embryonic stem cells and oncogenesis in vivo. Nat Biotechnol 25(2):207–215 5. Harrison NJ, Baker D, Andrews (2007) PWCulture adaptation of embryonic stem cells echoes germ cell malignancy.
Importantly, the VN-PAS substrate was also suitable for differentiation of hPSCs to cardiomyocytes, suggesting that this substrate may permit development of defined expansion and differentiation processes for generating large quantities of cells in clinically relevant lineages. hESCs and iPSCs do not efficiently attach to uncoated tissue culture treated polystyrene surfaces. However, it is possible to fabricate polymers that bind hESCs on tissue culture polystyrene dishes to facilitate hESC culture.
Advances in Stem Cell Research by Martin J. Pfeiffer, Martin Stehling, Anna Jauch (auth.), Hossein Baharvand, Nasser Aghdami (eds.)