Download e-book for iPad: Advanced Drug Formulation Design to Optimize Therapeutic by Robert O. Williams III, David R. Taft, Jason T. McConville

By Robert O. Williams III, David R. Taft, Jason T. McConville

ISBN-10: 1420043870

ISBN-13: 9781420043877

This name demonstrates how complex formula designs and supply applied sciences can be utilized to enhance drug efficacy and remedy results particularly healing different types or ailment states. It discusses nanoparticle structures for melanoma remedies, and in addition provides leading edge immono-regulation brokers for transplantation and the neighborhood focusing on of gear, specially poorly water soluble medications to supply more suitable healing results. additionally, this name highlights parts of remedy displaying the main promise for development in scientific results through complicated formula layout.

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Extra resources for Advanced Drug Formulation Design to Optimize Therapeutic Outcomes (Drugs and the Pharmaceutical Sciences)

Sample text

Subsequently, the most common investigated approaches to improve drug removal from carrier particles during inhalation are to (1) reduce the contact area between drug particle and carrier, (2) alter the particle geometry of the carrier, and (3) reduce the surface energy of the contiguous surfaces. Of these three approaches, by far the greatest attention has been focused on modifying the carrier morphology in order to achieve changes in the contact geometry between drug and carrier. A simplistic representation of the ranges of surface geometries which may be encountered is shown in Figure 5.

The presence of both these morphological features can be observed via high resolution Scanning electron micrograph (SEM) of a carrier particle surface (Fig. 9). The mechanism for improved performance in these systems is dependent on both the previously described formulation factors, and the relative cohesive/adhesive balance between the components involved. Recently, direct measurement of inter-particulate forces in conventional DPI systems has shown that a clear balance may be observed between the adhesion and cohesion profiles of each component in the formulation (33,34), and these factors may be used to predict the performance of the formulation.

125. 34 Young et al. virtual metering tanks, which only form a closed system on actuation. These improvements increase dose reproducibility, remove priming effects, and potentially increase therapeutic outcomes (126). Furthermore, these developments in valve technology, particularly the “Easi-fill” valve (BK361 Bespack, Fig. 19), can be incorporated into new pMDI designs with relative ease. Since pMDI formulations are pressurized systems, the crimp assembly and internal seals are important components since they should, for obvious reasons, avoid propellant leakage, and moisture ingress.

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Advanced Drug Formulation Design to Optimize Therapeutic Outcomes (Drugs and the Pharmaceutical Sciences) by Robert O. Williams III, David R. Taft, Jason T. McConville


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